About Us

Astrea Bioseparations Ltd (formerly Prometic Bioseparations Ltd) has long been established as an expert in affinity chromatography and bioseparations. Providing services for ligand design, adsorbent development, large scale adsorbent manufacture (up to 1,000L batch sizes) to GMP standards and GMP Ready pre-packed columns, Astrea Bioseparations is uniquely positioned and an ideal partner for biopharmaceutical and plasma derived therapeutics with a proven track record.

A total of 18 of Astrea’s adsorbents have been incorporated into FDA approved manufacturing processes which produce 12 approved pharmaceutical and medical products.

We can offer both standard ‘off-the-shelf’ adsorbents and bespoke adsorbents, which can be designed to meet specific purification/ manufacture criteria. These can be provided as adsorbents or pre-packed in EvolveD™ GMP Ready Columns. We also supply a range of ‘semi-disposable’ bioprocess columns – Evolve™ Bioprocess Columns.

Off the shelf adsorbents

Astrea has an extensive range of off-the-shelf bioseparation products, all available in a variety of formats to suit your requirements. Applications covered include:


  • Albumin and Albumin fusion proteins
  • Antibody and Antibody fragments
  • Recombinant proteins
  • Glycoprotein separation
  • Insulin & Insulin analogues
  • Plasma Proteins
  • Viral Vectors
  • Impurity removal:

  • Endotoxins
  • Serine Proteases
  • Host Cell Proteins
  • Isoagglutinins
  • Prions


Bespoke downstream purification

Astrea also offers bespoke services to identify or optimize an existing Astrea product. These include:

  • 30 years’ experience and success
  • Fully validated bespoke chromatography adsorbent
  • All associated process conditions for your target biomolecule
  • Maximum yield and purity
  • Minimum number of process steps
  • Screening Tools

The adsorbent uses bespoke chromatography designed to specifically target your desired biomolecule and application, or, alternatively, Astrea can develop and manufacture a completely new adsorbent to your own unique specification.

For global support for bioseparation solutions, please click here.