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Ion Exchange Chromatography Resins

Ion exchange chromatography (IEX) is a cornerstone of biopharmaceutical purification, offering powerful selectivity based on charge interactions. It is widely applied for the capture, intermediate purification, and polishing of proteins, antibodies, vaccines, and viral vectors, making it a trusted technique across research and regulated GMP manufacturing.

Astrea Bioseparations provides a comprehensive portfolio of PuraBead® IEX resins, including strong exchangers such as Q PuraBead® Edge and SP PuraBead® Edge, designed to deliver enhanced resolution for challenging separations. Established formats such as Q, SP, DEAE, and CM resins are also available, providing flexibility across diverse purification strategies.

All of our IEX resins are built on the proprietary PuraBead® base bead, manufactured using our unique atomisation technology. This base provides exceptional mechanical strength, low backpressure, and reproducible performance, ensuring robust scalability from discovery to commercial production.

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Ion Exchange (IEX) chromatography adsorbent with weak cation CM ligand
Ion Exchange (IEX) chromatography adsorbent with weak anion DEAE ligand
Ion Exchange (IEX) chromatography adsorbent with strong anion Q ligand
Ion Exchange (IEX) chromatography adsorbent with strong cation SP ligand
High resolution anion exchange chromatography resin on the trusted  PuraBead® platform. 

SPPuraBead® Edge is a next-generation strong CEX adsorbent, featuring asulphopropyl (SP) group attached to our advanced 65 µm PuraBead® Edge basebead. Our PuraBead® Edge resin is engineered for high resolution polishingapplications offering short residence times and low back pressure. This resinis designed to enhance separation resolution, ideal when required for thecapture and polish of positively charged species.

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