What is screening?
Historically, the identification of a specific ligand for a target protein has required the engagement of specialist companies. Whilst this approach can be very successful, such studies often require some time to set-up and perform as well as requiring specific details of the protein target and sample materials to be evaluated.
More recently, a limited number of very general ligands, sometimes described as mixed-mode ligands, have been developed incorporating simple ion-exchange (IEX) and hydrophobic (HIC) functionalities into a single ligand structure. These types of ligand have been particularly successful for general polishing/host cell protein (HCP) removal applications and have the advantage that users can undertake the evaluations themselves in-house, using standard laboratory equipment, in a relatively short time frame.
Multi-Mode Mimetic Ligand™ Library
Astrea Bioseparations Ltd (Astrea) have combined the advantages of both of these approaches resulting in the Multi-Mode Mimetic Ligand™ Library – an easy to use, rapid screening toolbox that can be used to identify chromatography adsorbents for a wide variety of applications, including both product capture and polishing. No sample conditioning required as you should select the ligand that binds under sample conditions, thereby eliminating the need to adjust sample with risk of product loss.
Key Features of the Multi-Mode Mimetic Ligand™ Library:
- Rapid screening toolbox
- No sample adjustment required
- 96 different ligands designed based on structural diversity
- Proven technology
- Cross linked agarose base matrix
- Cost effective & easy to use
- Universal platform
- Robust & stable adsorbents
- Scalable technology