Skip to main content

Your basket

Your basket is empty. Continue shopping to add products to your basket.

Search our catalogue

Call Centre

Request Quote

Please enter the quantity of products you want a quote for

Please enter the date you need these products byPlease enter a date in the format DD/MM/YYYY

View Content

Please complete the form below to receive the requested content from Astrea Bioseparations. We will use the data you provide to send you relevant updates, special offers, and product-related information. See our Privacy Notice for details on how we use personal data.

If you have an account please log in to gain access to content. You can apply for an account here

Please enter a First Name

Please enter a valid First Name, the maximum length is 50 characters.

Please enter a Last Name

Please enter a valid Last Name, the maximum length is 50 characters.

Please enter a Company Name

Please enter a valid Company, the maximum length is 100 characters

Please enter a valid Email AddressPlease enter a valid Email AddressThe Email Address entered is already registered, please sign in with the Email Address or enter a different one

Please select a valid Telephone Number, the maximum length is 30 characters

Please enter a valid Telephone Number consisting only of the following characters and spaces ( ) + 0 1 2 3 4 5 6 7 8 9

Please select a State / Province / Territory

Please select a valid State / Province / Territory, the maximum length is 150 characters

Please select a Country

Data entered into form will be stored in your session (not in a cookie) to avoid having to re-enter in future form submissions.

Plasmid DNA

Plasmid DNA purification is essential in molecular biology, supporting genetic engineering, gene therapy, and protein production. Circular DNA structures, or plasmids, contain specific genes, and their purity is critical for safe and successful downstream applications. Techniques like column chromatography or precipitation remove contaminants, ensuring highly concentrated and pure plasmid DNA. This purity is crucial for accurate cloning, transfection, gene expression studies, and the development of gene-based therapies. High-quality plasmid DNA is necessary for regulatory compliance and research reproducibility, highlighting the fundamental role of plasmid DNA purification in modern biotechnology.

Our Solutions

pDNAHERO® polish, a novel HIC adsorbent, offers an efficient orthogonal chromatography step for contaminant removal after AEX primary capture or post linearization.

Even at fast flow rates, binding capacity remains high, and delta pressure across the device remains low. Performance is conserved as plasmid size increases, ensuring consistent yields as projects change.

Hydrophobic interaction chromatography (HIC) is an established method for separating DNA isoforms, and RNA by exploiting the different nucleic acid impurities.

Capacity and flow rates no longer need to be compromised when purifying larger DNA sequences, namely those required for cell & gene therapy applications.

Shop the Range

Flexible and scalable, DEAE PuraBead® P6HF provides the selectivity required for pDNA capture from the bench to the factory floor.

The variable selectivity provided by DEAE weak anion exchange chromatography resins preferentially capture pDNA while allowing contaminants, such as other nucleic acids and HCPs, to pass through the column.

  • High capacity DEAE resin
  • Can be used in a range of conditions to select for capture of pDNA only
  • Large bead sizes and fast flow rates boost productivity
  • Available in slurry and columns across a range of sizes to meet production needs
  • Low shear forces reduce risk of damaging scDNA

Shop the Range

Ensure your sample contains only supercoiled pDNA with Hexyl PuraBead® P6HF.

Product degradation due to mechanical sheer stresses can contaminate supercoiled pDNA with open circular form which can be less effective.

  • Removal of ocDNA increases the biological activity of pDNA product
  • Open coiled ocDNA is not bound by Hexyl PuraBead® P6HF
  • scDNA is captured and can be eluted
  • Demonstrated scalability from bench scale to manufacturing

Shop the Range

pDNAHERO® Polish 1

pDNAHERO® Polish 10

Bulk Resin

Pre-packed Columns



    User Guides


    Have any questions? 

    Request a follow-up and one of our experts will contact you directly:

    Call Centre Product Compare