Products High Purity Bioprocessing Adsorbents

Uncompromising Purity

Astrea Bioseparations’ wide range of affinity, HIC and IEX chromatography resins enables you to maximize recovery of your target protein without compromising on purity.

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Etoxiclear™

Etoxiclear™ is a high performance, highly stable, affinity chromatography adsorbent allowing cost effective and efficient endotoxin removal. Available as an adsorbent slurry for column packing and in a range of disposable columns to suit your process.

Etoxiclear™ is a high performance, highly stable, affinity chromatography adsorbent allowing cost effective and efficient endotoxin removal. Available as an adsorbent slurry for column packing and in a range of disposable columns to suit your process.

Key Features

  • High endotoxin dynamic binding capacity (> 1,000,000 EU/ml)
  • Compatible with wide range of proteins
  • Low protein binding (typically >90% recovery)
  • Ideal for polishing biological products produced in E.coli
  • Suitable for use in GMP environments

Product Code

3250 – Etoxiclear™

Aminophenylboronate

Effective purification and removal of glycoproteins and glycans is achieved with this affinity chromatography adsorbent, due to the m-aminophenylboronic acid ligand that binds selectively to carbohydrate groups with cis-diols.

Effective purification and removal of glycoproteins and glycans is achieved with this affinity chromatography adsorbent, due to the m-aminophenylboronic acid ligand that binds selectively to carbohydrate groups with cis-diols.

Key Features

  • High dynamic binding capacity of 10-20 g/L glycoprotein
  • Sanitizable with 0.5 to 1.0M NaOH
  • Long life adsorbent allowing Multiple cycles
  • Supported with comprehensive Regulatory Support Files

Product Code

3355 – Aminophenylboronate P6XL

Mimetic Blue® AP

The Mimetic Blue® AP alkaline phosphatase selective affinity adsorbent can be used with sources such as microbial fermentation broth, plasma, serum, and recombinant cell cultures to yield highly purified biological products.

The Mimetic Blue® AP alkaline phosphatase selective affinity adsorbent can be used with sources such as microbial fermentation broth, plasma, serum, and recombinant cell cultures to yield highly purified biological products.

Key Features

  • High specificity for alkaline phosphatase
  • Sanitizable, long-life adsorbent allowing multiple cycles
  • Supported with comprehensive Regulatory Support Files

Product Code

3115 – Mimetic Blue® AP HL P6HF

Mimetic Blue® SA

An affinity adsorbent designed for the capture and purification of albumin and albumin-related proteins from a variety of sources, including plasma, serum and recombinant fermentation and cell cultures.

An affinity adsorbent designed for the capture and purification of albumin and albumin-related proteins from a variety of sources, including plasma, serum and recombinant fermentation and cell cultures.

Key Features

  • High dynamic binding capacity
  • Sanitizable (alkali stable) long-life adsorbent, allowing multiple cycles
  • Supported with comprehensive Regulatory Support Files

Product Code

3135 – Mimetic Blue® SA P6HF
This product is designed for higher selectivity in complex solutions, (25 mg HSA/ml binding capacity) with a medium ligand density.

3125 – Mimetic Blue® SA HL P6XL
This product is designed to maximise binding capacity (40 mg HSA/ml binding capacity), with a high ligand density.

AlbuPure®

Developed in partnership with Albumedix and manufactured exclusively by Astrea Bioseparations Ltd, AlbuPure® is designed for the purification of albumin fusion proteins. This affinity chromatography adsorbent is highly stable and non-toxic, providing high recovery, purity and selectivity.

Developed in partnership with Albumedix and manufactured exclusively by Astrea Bioseparations Ltd, AlbuPure® is designed for the purification of albumin fusion proteins. This affinity chromatography adsorbent is highly stable and non-toxic, providing high recovery, purity and selectivity.

Key Features

  • Excellent flow properties
  • High dynamic binding capacity
  • Sanitizable long life adsorbent, allowing multiple cycles
  • Supported with a comprehensive Regulatory Support File

Product Code

3151 – AlbuPure®

Fabsorbent™

This antibody light-chain binding affinity adsorbent provides a caustic-stable platform technology for the capture and purification of antibodies and antibody fragments from multiple species (including human, bovine, ovine and murine).

This antibody light-chain binding affinity adsorbent provides a caustic-stable platform technology for the capture and purification of antibodies and antibody fragments from multiple species (including human, bovine, ovine and murine).

Key Features

  • ScFv, Fab’ and single domain antibody fragments expressed in E.coli
  • Mammalian Fab and F(ab’)2 fragments from papain catalysed antibody digests
  • Human antibody λ and κ light chains

Product Code

3904 – Fabsorbent™ F1P HF

MAbsorbent®

Recommended for the capture of a wide variety of human and mammalian polyclonal antibodies (including bovine, mouse, sheep, goat, horse and rabbit).

Recommended for the capture of a wide variety of human and mammalian polyclonal antibodies (including bovine, mouse, sheep, goat, horse and rabbit).

Key Features

  • Binds polyclonal IgG and all sub-classes
  • Sanitizable long life adsorbent, allowing multiple cycles
  • Available in 2 ligand densities to control for specificity without loss of capacity

Product Code

3903 – MAbsorbent® A2P HF
This product is recommended for human or humanized antibodies.

3906 – MAbsorbent® A2PHF LL
This product is recommended for purification of IVIG (intravenous immunoglobulin) from plasma.

Insulin Adsorbent

A high performance, affinity adsorbent that enables process simplification and reduction in the overall cost of insulin production. This adsorbent specifically captures naturally occurring forms of insulin, as well as insulin analogues from a variety of sources. It is alkali resistant, robust, non-toxic and is compatible with large scale cGMP manufacturing.

A high performance, affinity adsorbent that enables process simplification and reduction in the overall cost of insulin production. This adsorbent specifically captures naturally occurring forms of insulin, as well as insulin analogues from a variety of sources. It is alkali resistant, robust, non-toxic and is compatible with large scale cGMP manufacturing.

Key Features

  • Selective for most forms of insulin including single chain & two chain insulin
  • High purities & yields
  • Cost effective & reliable
  • Easy to clean robust, long life adsorbent

Product Code

3160 – Insulin Adsorbent

p-Aminobenzamidine

Designed for the affinity purification or removal of serine proteases and esterases (including trypsin, thrombin, kallikrein, urokinase, acetylcholinesterase and alkaline phosphatase). Ideal for the resolution of multiple serine protease species (for example, trypsin and chymotrypsin) and for the removal of trace proteases to stabilize protein product from proteolytic degradation.

Designed for the affinity purification or removal of serine proteases and esterases (including trypsin, thrombin, kallikrein, urokinase, acetylcholinesterase and alkaline phosphatase). Ideal for the resolution of multiple serine protease species (for example, trypsin and chymotrypsin) and for the removal of trace proteases to stabilize protein product from proteolytic degradation.

Key Features

  • Highly selective synthetic ligand
  • High dynamic binding capacity
  • Sanitizable with 20% ethanol/1.0M acetic acid allowing multiple cycles
  • Supported with a comprehensive Regulatory Support File

Product Code

0320 – p-Aminobenzamidine AP6XL

PE PuraBead®

A versatile chromatography adsorbent, designed to purify phosphate binding proteins by affinity interaction.

A versatile chromatography adsorbent, designed to purify phosphate binding proteins by affinity interaction.

Key Features

  • Binds pentraxin related proteins
  • Purification of DNA modifying proteins/enzymes (DNA polymerases, endonucleases, ligases and nucleases
  • Can act also be used as a cation exchanger to fractionate and purify positively charged proteins

Product Code

9501 – PE PuraBead® 6HF

HIC

Our Hydrophobic Interaction Chromatography (HIC) range includes both Phenyl, Octyl, Butyl & Hexyl adsorbents, and is used to separate proteins based on relative hydrophobicity. The HIC column kits enable rapid, and cost-effective method development, as well as small scale purification runs. Alternatively, these small pre-packed columns are ideal for single-use for contaminant removal. Also available in slurry packs for small to large manufacturing scale. Single resin column kits are also available on request, which are ideal for small scale purification runs, or as single-use disposable columns for contaminant removal.

Our Hydrophobic Interaction Chromatography (HIC) range includes both Phenyl, Octyl, Butyl & Hexyl adsorbents, and is used to separate proteins based on relative hydrophobicity. The HIC column kits enable rapid, and cost-effective method development, as well as small scale purification runs. Alternatively, these small pre-packed columns are ideal for single-use for contaminant removal. Also available in slurry packs for small to large manufacturing scale. Single resin column kits are also available on request, which are ideal for small scale purification runs, or as single-use disposable columns for contaminant removal.

Product Code

3455 – Octyl PuraBead® HF
3408 – Phenyl PuraBead® HF
6614 – HIC Selection kit, 4 x 1 mL
6615 – HIC Selection kit, 4 x 5 mL

IEX

Our Ion Exchange (IEX) chromatography range includes DEAE, CM, Q and SP adsorbents, and is used to separate proteins based on their net charge at a particular pH. Available as slurry packs, or in easy-to-use column selection kits designed for method development. Single resin column kits are also available on request, which are ideal for small scale purification runs, or as single-use disposable columns for contaminant removal.

Our Ion Exchange (IEX) chromatography range includes DEAE, CM, Q and SP adsorbents, and is used to separate proteins based on their net charge at a particular pH. Available as slurry packs, or in easy-to-use column selection kits designed for method development. Single resin column kits are also available on request, which are ideal for small scale purification runs, or as single-use disposable columns for contaminant removal.

Product Code

3450 – CM PuraBead® HF
3451 – DEAE PuraBead® HF
3452 – Q PuraBead® HF
3453 – SP PuraBead® HF
6608 – IEX Selection kit, 4 x 1 mL
6609 – IEX Selection kit, 4 x 5 mL

IsoClear

These highly selective affinity adsorbents are designed to remove Isoagglutinin antibodies from Plasma, Serum and IVIG solutions, enabling cost effective and efficient manufacture of isoagglutinin -reduced plasma products from more abundant A, B and O blood types.

These highly selective affinity adsorbents are designed to remove Isoagglutinin antibodies from Plasma, Serum and IVIG solutions, enabling cost effective and efficient manufacture of isoagglutinin -reduced plasma products from more abundant A, B and O blood types.

Key Features

  • Applicable to most blood derived compositions
  • Specific for anti-A & anti-B isoagglutinins (IgM and IgG isotypes)
  • High performance (typically >99% isoagglutinin removal from plasma)
  • Excellent protein recovery (typically >99%)

Product Code

9301 – IsoClear A™
9302 – IsoClear B™

Etoxiclear™

Etoxiclear™ is a high performance, highly stable, affinity chromatography adsorbent allowing cost effective and efficient endotoxin removal. Available as an adsorbent slurry for column packing and in a range of disposable columns to suit your process.

Key Features

  • High endotoxin dynamic binding capacity (> 1,000,000 EU/ml)
  • Compatible with wide range of proteins
  • Low protein binding (typically >90% recovery)
  • Ideal for polishing biological products produced in E.coli
  • Suitable for use in GMP environments

Product Code

3250 – Etoxiclear™

Aminophenylboronate

Effective purification and removal of glycoproteins and glycans is achieved with this affinity chromatography adsorbent, due to the m-aminophenylboronic acid ligand that binds selectively to carbohydrate groups with cis-diols.

Key Features

  • High dynamic binding capacity of 10-20 g/L glycoprotein
  • Sanitizable with 0.5 to 1.0M NaOH
  • Long life adsorbent allowing Multiple cycles
  • Supported with comprehensive Regulatory Support Files

Product Code

3355 – Aminophenylboronate P6XL

Mimetic Blue® AP

The Mimetic Blue® AP alkaline phosphatase selective affinity adsorbent can be used with sources such as microbial fermentation broth, plasma, serum, and recombinant cell cultures to yield highly purified biological products.

Key Features

  • High specificity for alkaline phosphatase
  • Sanitizable, long-life adsorbent allowing multiple cycles
  • Supported with comprehensive Regulatory Support Files

Product Code

3115 – Mimetic Blue® AP HL P6HF

Mimetic Blue® SA

An affinity adsorbent designed for the capture and purification of albumin and albumin-related proteins from a variety of sources, including plasma, serum and recombinant fermentation and cell cultures.

Key Features

  • High dynamic binding capacity
  • Sanitizable (alkali stable) long-life adsorbent, allowing multiple cycles
  • Supported with comprehensive Regulatory Support Files

Product Code

3135 – Mimetic Blue® SA P6HF
This product is designed for higher selectivity in complex solutions, (25 mg HSA/ml binding capacity) with a medium ligand density.

3125 – Mimetic Blue® SA HL P6XL
This product is designed to maximise binding capacity (40 mg HSA/ml binding capacity), with a high ligand density.

AlbuPure®

Developed in partnership with Albumedix and manufactured exclusively by Astrea Bioseparations Ltd, AlbuPure® is designed for the purification of albumin fusion proteins. This affinity chromatography adsorbent is highly stable and non-toxic, providing high recovery, purity and selectivity.

Key Features

  • Excellent flow properties
  • High dynamic binding capacity
  • Sanitizable long life adsorbent, allowing multiple cycles
  • Supported with a comprehensive Regulatory Support File

Product Code

3151 – AlbuPure®

Fabsorbent™

This antibody light-chain binding affinity adsorbent provides a caustic-stable platform technology for the capture and purification of antibodies and antibody fragments from multiple species (including human, bovine, ovine and murine).

Key Features

  • ScFv, Fab’ and single domain antibody fragments expressed in E.coli
  • Mammalian Fab and F(ab’)2 fragments from papain catalysed antibody digests
  • Human antibody λ and κ light chains

Product Code

3904 – Fabsorbent™ F1P HF

MAbsorbent®

Recommended for the capture of a wide variety of human and mammalian polyclonal antibodies (including bovine, mouse, sheep, goat, horse and rabbit).

Key Features

  • Binds polyclonal IgG and all sub-classes
  • Sanitizable long life adsorbent, allowing multiple cycles
  • Available in 2 ligand densities to control for specificity without loss of capacity

Product Code

3903 – MAbsorbent® A2P HF
This product is recommended for human or humanized antibodies.

3906 – MAbsorbent® A2PHF LL
This product is recommended for purification of IVIG (intravenous immunoglobulin) from plasma.

Insulin Adsorbent

A high performance, affinity adsorbent that enables process simplification and reduction in the overall cost of insulin production. This adsorbent specifically captures naturally occurring forms of insulin, as well as insulin analogues from a variety of sources. It is alkali resistant, robust, non-toxic and is compatible with large scale cGMP manufacturing.

Key Features

  • Selective for most forms of insulin including single chain & two chain insulin
  • High purities & yields
  • Cost effective & reliable
  • Easy to clean robust, long life adsorbent

Product Code

3160 – Insulin Adsorbent

p-Aminobenzamidine

Designed for the affinity purification or removal of serine proteases and esterases (including trypsin, thrombin, kallikrein, urokinase, acetylcholinesterase and alkaline phosphatase). Ideal for the resolution of multiple serine protease species (for example, trypsin and chymotrypsin) and for the removal of trace proteases to stabilize protein product from proteolytic degradation.

Key Features

  • Highly selective synthetic ligand
  • High dynamic binding capacity
  • Sanitizable with 20% ethanol/1.0M acetic acid allowing multiple cycles
  • Supported with a comprehensive Regulatory Support File

Product Code

0320 – p-Aminobenzamidine AP6XL

PE PuraBead®

A versatile chromatography adsorbent, designed to purify phosphate binding proteins by affinity interaction.

Key Features

  • Binds pentraxin related proteins
  • Purification of DNA modifying proteins/enzymes (DNA polymerases, endonucleases, ligases and nucleases
  • Can act also be used as a cation exchanger to fractionate and purify positively charged proteins

Product Code

9501 – PE PuraBead® 6HF

HIC

Our Hydrophobic Interaction Chromatography (HIC) range includes both Phenyl, Octyl, Butyl & Hexyl adsorbents, and is used to separate proteins based on relative hydrophobicity. The HIC column kits enable rapid, and cost-effective method development, as well as small scale purification runs. Alternatively, these small pre-packed columns are ideal for single-use for contaminant removal. Also available in slurry packs for small to large manufacturing scale. Single resin column kits are also available on request, which are ideal for small scale purification runs, or as single-use disposable columns for contaminant removal.

Product Code

3455 – Octyl PuraBead® HF
3408 – Phenyl PuraBead® HF
6614 – HIC Selection kit, 4 x 1 mL
6615 – HIC Selection kit, 4 x 5 mL

IEX

Our Ion Exchange (IEX) chromatography range includes DEAE, CM, Q and SP adsorbents, and is used to separate proteins based on their net charge at a particular pH. Available as slurry packs, or in easy-to-use column selection kits designed for method development. Single resin column kits are also available on request, which are ideal for small scale purification runs, or as single-use disposable columns for contaminant removal.

Product Code

3450 – CM PuraBead® HF
3451 – DEAE PuraBead® HF
3452 – Q PuraBead® HF
3453 – SP PuraBead® HF
6608 – IEX Selection kit, 4 x 1 mL
6609 – IEX Selection kit, 4 x 5 mL

IsoClear

These highly selective affinity adsorbents are designed to remove Isoagglutinin antibodies from Plasma, Serum and IVIG solutions, enabling cost effective and efficient manufacture of isoagglutinin -reduced plasma products from more abundant A, B and O blood types.

Key Features

  • Applicable to most blood derived compositions
  • Specific for anti-A & anti-B isoagglutinins (IgM and IgG isotypes)
  • High performance (typically >99% isoagglutinin removal from plasma)
  • Excellent protein recovery (typically >99%)

Product Code

9301 – IsoClear A™
9302 – IsoClear B™