Hydrophobic interaction chromatography (HIC) is a well-established technique for the separations and purification of biomolecules based on differences in surface hydrophobicity. HIC resins are widely applied in downstream purification for protein fractionation, antibody purification, viral vector processing, and aggregate removal, making them a versatile tool across biopharmaceutical bioprocessing workflows.

Astrea Bioseparations offers a comprehensive portfolio of PuraBead® hydrophobic interaction chromatography resins, including Butyl, Hexyl, Octyl, and Phenyl ligands. These HIC resins provide tailored selectivity to address a broad range of molecular characteristics and process requirements, supporting scalable purification applications from early discovery and process development through GMP biologics manufacturing.

All PuraBead® HIC resins are built on the proprietary PuraBead® base bead and manufactured using our unique atomization technology. The base matrix delivers high mechanical strength, low backpressure, and consistent scalability, enabling reliable performance across development, scale-up, and commercial production.