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Practical expertise

Chromatography performance doesn’t happen in isolation. Resin selection, feedstock variability, impurity profile, process constraints, scale-up considerations, regulatory expectations, and facility limitations all interact. Our Field Application Scientist team helps you navigate that complexity. Working at the interface between development and bioprocess application, our FAS team partners with process development and manufacturing groups to translate purification challenges into practical, technically sound solutions.

What we bring to your process

Our team combines deep chromatography knowledge with hands-on downstream process experience across proteins, viral vectors, plasmid DNA, and other advanced biologics. We support programs from early method scouting through process optimization and commercial scale-up, ensuring purification strategies are both technically robust and operationally viable.

Our expertise includes:

Technical strategy

Design and execution of purification workflows aligned to molecule type, impurity profile, and process objectives

Optimization and scale-up

Method refinement from early development through pilot and commercial manufacturing

Troubleshooting

Enabling confident adoption of new methods and technologies

Knowledge transfer

Enabling confident adoption of new methods and technologies

Real-world impact

See three examples of how our Field Application Scientists work alongside customers to troubleshoot issues and keep processes running smoothly.

    Rapid remote troubleshooting restores system performance

    Challenge

    A customer experienced high operating pressure and air bubbles after installing a pre-packed column on their LC system

    Cause

    Incorrect connections and narrow flow path components

    Response

    The FAS team responded within 2 working hours, quickly diagnosing the issue

    Solution

    Remote support was provided using visual documentation outlining correct connectors, tubing, and fittings, including detailed specifications

    Outcome

    The issue was resolved the same day without requiring a site visit, minimizing downtime and restoring optimal system performance

    Onsite expertise restores performance and builds confidence

    Challenge

    A customer encountered multiple issues with process columns, including a broken flow tube and leakage between components

    Cause

    Improper handling due to limited training

    Response

    The FAS team mobilized quickly, arranging onsite support within days of the initial report

    Solution

    Onsite intervention included component replacement, issue resolution, and hands-on operational training

    Outcome

    The customer resumed normal operations with improved confidence and understanding, supported by both rapid response and practical expertise

    Expert guidance that supports successful scale-up

    Challenge

    A customer required support packing a large-scale column to a defined bed height, with limited prior experience at this scale

    Cause

    Knowledge gaps around packing procedures and the impact of process parameters such as pressure, buffer conditions, and flow rates

    Response

    The FAS team provided detailed support over three days, including written guidance and virtual consultation

    Solution

    Using internal expertise and prior knowledge, the team delivered clear instructions on packing procedures and tailored troubleshooting advice

    Outcome

    The customer successfully progressed with their process, gaining both technical understanding and confidence in large-scale operation

    Application-focused technical support

    Our Field Application Scientists provide practical, data-driven guidance, including:

    • Resin selection aligned to impurity profile and performance goals
    • Experimental design for binding, wash, and elution optimization
    • Evaluation of dynamic binding capacity and flow constraints
    • Interpretation of chromatographic data grounded in first principles
    The focus is on developing purification steps that are reproducible, scalable, and fully integrated within your broader downstream process.

    Global reach, responsive support

    With regional coverage across the United Kingdom, Europe, United States, and APAC, our Field Application Scientists provide both remote and on-site support. Whether assisting with process evaluation studies, technology transfer discussions, or in-lab troubleshooting, expertise is available when and where it’s needed.
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    Connect with the team

    If you are evaluating a new purification strategy or strengthening an existing step, our Field Application Scientist team is ready to collaborate.

    Contact us to discuss your application and explore how we can support your process.

    Use the button below to email our team directly.

    Contact us

     

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