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Mixed-mode chromatography resins

Mixed-mode chromatography combines two or more interaction mechanisms within a single resin, offering unique selectivity that cannot be achieved through traditional ion exchange or hydrophobic interaction alone. This makes it a powerful tool for the purification of complex and difficult-to-separate biomolecules such as antibodies, viral vectors, and proteins with closely related impurities.

Astrea Bioseparations’ MiMode™ PuraBead® mixed-mode resins harness combinations of hydrophobic, anion exchange, and cation exchange interactions to expand the separation space. This enables superior removal of aggregates, host cell proteins, and other process-related impurities, maximizing both yield and purity. Product families include hydrophobic, anion exchange, and cation exchange mixed-mode resins tailored for diverse applications.

Built on our proprietary PuraBead® base bead, manufactured via unique atomization technology, these resins provide high mechanical strength, low backpressure, and excellent scalability. This ensures robust, reproducible performance across scales, from early development to full GMP production.

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MiMode™ PuraBead® HL4
MiMode™ PuraBead® HL4
MiMode™ PuraBead® HL4 is one of four resins in the hydrophobic mixed-mode range that harnesses both hydrophobic and hydrogen-bonding interactions to target proteins and viral particles where other approaches often fail. The hydrophobic family includes MiMode™ PuraBead® HX1, HX2, HL3, and HL4 resins, each tuned to offer slightly different binding profiles, allowing developers to identify the optimal solution for their molecule.
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MiMode™ PuraBead® CBX1
MiMode™ PuraBead® CBX1
MiMode™ PuraBead® CBX1 is part of the cation exchange mixed-mode family, harnessing cationic, hydrophobic, boronate ester and hydrogen-bonding interactions for powerful purification of positively charged biomolecules, including monoclonal antibodies, enzymes, and proteins with isoelectric points above neutral. By combining multiple binding interaction contributions, these resins provide enhanced flexibility in binding and release, supporting both capture and polishing steps in bioprocess workflows.
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MiMode™ PuraBead® HX2
MiMode™ PuraBead® HX2
MiMode™ PuraBead® HX2 is one of four resins in the hydrophobic mixed-mode range that harnesses both hydrophobic and hydrogen-bonding interactions to target proteins and viral particles where other approaches often fail. The hydrophobic family includes MiMode™ PuraBead® HX1, HX2, HL3, and HL4 resins, each tuned to offer slightly different binding profiles, allowing developers to identify the optimal solution for their molecule.
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MiMode™ PuraBead® HL3
MiMode™ PuraBead® HL3
MiMode™ PuraBead® HL3 is one of four resins in the hydrophobic mixed-mode range that harnesses both hydrophobic and hydrogen-bonding interactions to target proteins and viral particles where other approaches often fail. The hydrophobic family includes MiMode™ PuraBead® HX1, HX2, HL3, and HL4 resins, each tuned to offer slightly different binding profiles, allowing developers to identify the optimal solution for their molecule.
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BTXPure™
BTXPure™

BTXPure™ is a unique mixed mode resin for the targeted capture and purification of botulinum toxins.

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MiMode™ PuraBead® AX1
MiMode™ PuraBead® AX1
MiMode™ PuraBead® AX1 is an anion exchange mixed-mode family, harnessing anionic and hydrophobic to provide strong selectivity for negatively charged biomolecules. These resins excel in applications such as nucleic acid clearance, viral purification, and polishing of therapeutic proteins. The mixed-mode design ensures a balance between binding strength and elution control, even in the presence of complex feed streams or high salt environments.
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MiMode™ PuraBead® HX1
MiMode™ PuraBead® HX1
MiMode™ PuraBead® HX1 is one of four resins in the hydrophobic mixed-mode range that harnesses both hydrophobic and hydrogen-bonding interactions to target proteins and viral particles where other approaches often fail. The hydrophobic family includesMiMode™ PuraBead® HX1, HX2, HL3, and HL4 resins, each tuned to offer slightly different binding profiles, allowing developers to identify the optimal solution for their molecule.
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MiMode™ CBX2
MiMode™ CBX2
MiMode™ CBX2 is part of the cation exchange mixed-mode family, harnessing cationic, hydrophobic, boronate ester and hydrogen-bonding interactions for powerful purification of positively charged biomolecules, including monoclonal antibodies, enzymes, and proteins with isoelectric points above neutral. By combining multiple binding interaction contributions, these resins provide enhanced flexibility in binding and release, supporting both capture and polishing steps in bioprocess workflows.
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MiMode™ PuraBead® CX1
MiMode™ PuraBead® CX1
MiMode™ PuraBead® CX1 is part of the cation exchange mixed-mode family, harnessing cationic, hydrophobic, and hydrogen-bonding interactions for powerful purification of positively charged biomolecules, including monoclonal antibodies, enzymes, and proteins with isoelectric points above neutral. By combining multiple binding interaction contributions, these resins provide enhanced flexibility in binding and release, supporting both capture and polishing steps in bioprocess workflows.
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MiMode™ PuraBead® CX2
MiMode™ PuraBead® CX2
MiMode™ PuraBead® CX2 is part of the cation exchange mixed-mode family, harnessing cationic, hydrophobic, and hydrogen-bonding interactions for powerful purification of positively charged biomolecules, including monoclonal antibodies, enzymes, and proteins with isoelectric points above neutral. By combining multiple binding interaction contributions, these resins provide enhanced flexibility in binding and release, supporting both capture and polishing steps in bioprocess workflows.
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