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MiMode™ CBX2
MiMode™ CBX2
MiMode™ CBX2
MiMode™ CBX2 Alternative Image
MiMode™ CBX2 Alternative Image
MiMode™ CBX2 Alternative Image

MiMode™ CBX2

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MiMode™ CBX2 is part of the cation exchange mixed-mode family, harnessing cationic, hydrophobic, boronate ester and hydrogen-bonding interactions for powerful purification of positively charged biomolecules, including monoclonal antibodies, enzymes, and proteins with isoelectric points above neutral. By combining multiple binding interaction contributions, these resins provide enhanced flexibility in binding and release, supporting both capture and polishing steps in bioprocess workflows.
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Product overview

MiMode™ CBX2 is a next-generation mixed-mode chromatography resin featuring a proprietary ligand that combines cationic, hydrophobic, boronate ester, and hydrogen-bonding interactions. This multi-modal selectivity provides powerful separation options making it especially effective for challenging purifications where single-mode approaches fall short.

MiMode™ CBX2 is designed as a platform solution, enabling both capture and polishing of complex biomolecules across early development and large-scale production.

Key features of MiMode™ CBX2

  • Mixed-mode ligand with cationic, hydrophobic, boronate ester, and hydrogen-bonding interactions.
  • Unique ligand attached to an agarose base-matrix support
  • Suitable for both bind-and-elute and flow-through polishing applications.
  • Broad operating pH range and tolerance to cleaning with NaOH.
  • Scalable formats from high-throughput plates to bulk resin.

 

Simplified workflow integration and scalability

MiMode™ CBX2 is available in screening plates, RoboColumns®, pre-packed screening and development columns, and bulk slurry. Its versatile chemistry makes it ideal for inclusion in resin screening campaigns, allowing identification of conditions where its multi-modal interactions provide superior results.

 

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