Articles

Performance Testing of Packed Columns

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EvolveD™ - Infographic

Visualise the features and advantages of our pre-packed, disposable technology - the EvolveD™ column range.

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Re-use, Cleaning and sanitization of IsoClear™ Affinity Adsorbents

A scale-down reuse study was performed on an automated chromatography workstation using a 2 mL IsoClear B™ column challenged with 50 CV of plasma per cycle.

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Quality First!

At Prometic Bioseparations we put product quality first and have committed to become the first chromatography adsorbent manufacturer to achieve full GMP compliance!

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Screening for Chromatography Adsorbent Selection and Optimisation for Downstream Processing of Biopharmaceuticals

This article reviews the past and current options for screening of chromatography adsorbents for downstream process development and the use of emergent mixed mode ligand adsorbents for improved adsorb

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Multi-Mode Ligand Library - Infographic

Visualise our Multi-Mode Ligand Library through this infographic. An 18 month custom programme patented since 1989.

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Endotoxins - Infographic

Visualise how EtoxiClear™ - our high performance, non-ion-exchange, synthetic affinity chromatography adsorbent can help you with Endotoxin removal.

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Scaling up Production

Prometic Bioseparations has been manufacturing chromatography adsorbents on the Isle of Man since 1989. In this article we will update you on the expansion of our adsorbent manufacturing capacity.

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Ligand Discovery Projects

Our goal is to provide you with a fully validated bespoke chromatography adsorbent and all the associated process conditions for purification of your target biomolecule.

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Capture and purification of Fab fragments from human polyclonal IgG papain digest using Fabsorbent™ F1P HF

In response to demand we have developed an affinity adsorbent for the capture and purification of antibody fragments.

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Is it really cost effective to develop a custom affinity ligand as a capture step in your downstream process?

We offer an extensive range of off-the-shelf Bioseparation products for the recovery and purification of biologicals as well as purification services including bespoke custom designed chromatography.

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Removal of Isoagglutinins from IVIG and Plasma Using Affinity Chromatography

Removal of Isoagglutinins from IVIG and Plasma Using Affinity Chromatography

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Evolve™ Process Column: Customer Evaluation

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The Evolve™ Process Column in NIBRT

User friendly and ergonomic; performance is comparable to more expensive columns and the single use aspect compares well to lengthy cleaning cycles.

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Endotoxin removal & β-D-Glucan Interference

EtoxiClear™ has been shown to provide >3.4 log clearance of endotoxin from Fab fragments from an E. coli cell lysate, as well as from proteins such as IgG and HSA.

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EtoxiClear™: An novel affinity adsorbent for the efficient removal of endotoxin

A number of methods have been adopted for the removal of endotoxin based on adsorption, in particular ion-exchange chromatography.

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Capture and purification of human serum albumin from human source plasma using Mimetic Blue® SA HL P6XL

In this application note we describe how human serum albumin is captured and purified from human source plasma using Mimetic Blue® SA HL P6XL.

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Capture and purification of recombinant albumin-fusion proteins using AlbuPure®.

AlbuPure® can be used to capture and purify recombinant albumin-fusion proteins from cell culture supernatants with high purity and recovery.

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Endotoxin Removal from Bench to Process Scale

Endotoxin or lipopolysaccharides (LPS) are highly toxic components of the cell wall of Gram-negative bacteria and are often present in significant amounts in bacterial cell expression systems.

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