Articles

Removal of Endotoxins - From Bench to Process Scale

Astrea Bioseparations technical poster on removal of Endotoxins.

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Removal of Isoagglutinins from IVIG and Plasma Using Affinity Chromatography

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A Rapid Screening Toolbox for Product Polishing

Astrea Bioseparations scientific poster for Multi-Mode Mimetic Ligand Library - A Rapid Screening Toolbox for Product Polishing

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EvolveD™ Infographic

An infographic on the highlights of Astrea Bioseparations EvolveD™ column range.

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Multi-Mode Mimetic Ligand™ Library Infographic

Astrea Bioseparations Infographic for their Multi-Mode Mimetic Ligand™ Library

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Endotoxin Removal Infographic

Astrea Bioseparations Endotoxin Removal Infographic for EtoxiClear

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Determination of Dynamic Binding Capacity for Chromatography Adsorbent

How to determine the dynamic binding capacity of a chromatography adsorbent.

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Performance Testing of Packed Columns

Guidelines from Astrea Bioseparations for Performance Testing of Packed Columns

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Re-use, Cleaning and sanitization of IsoClear™ Affinity Adsorbents

A scale-down reuse study was performed on an automated chromatography workstation using a 2 mL IsoClear B™ column challenged with 50 CV of plasma per cycle.

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Quality First!

At Astrea Bioseparations we put product quality first and have committed to become the first chromatography adsorbent manufacturer to achieve full GMP compliance!

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Screening for Chromatography Adsorbent Selection and Optimisation for Downstream Processing of Biopharmaceuticals

This article reviews the past and current options for screening of chromatography adsorbents for downstream process development and the use of emergent mixed mode ligand adsorbents for improved adsorb

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Scaling up Production

Astrea Bioseparations has been manufacturing chromatography adsorbents on the Isle of Man since 1989. In this article we will update you on the expansion of our adsorbent manufacturing capacity.

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Ligand Discovery Projects

Our goal is to provide you with a fully validated bespoke chromatography adsorbent and all the associated process conditions for purification of your target biomolecule.

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Capture and purification of Fab fragments from human polyclonal IgG papain digest using Fabsorbent™ F1P HF

In response to demand we have developed an affinity adsorbent for the capture and purification of antibody fragments.

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Is it really cost effective to develop a custom affinity ligand as a capture step in your downstream process?

We offer an extensive range of off-the-shelf Bioseparation products for the recovery and purification of biologicals as well as purification services including bespoke custom designed chromatography.

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Evolve™ Process Column: Customer Evaluation

Feedback from trials of Evolve™ column at a major Biopharmaceutical company, based in USA.

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The Evolve™ Process Column in NIBRT

User friendly and ergonomic; performance is comparable to more expensive columns and the single use aspect compares well to lengthy cleaning cycles.

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Endotoxin removal & β-D-Glucan Interference

EtoxiClear™ has been shown to provide >3.4 log clearance of endotoxin from Fab fragments from an E. coli cell lysate, as well as from proteins such as IgG and HSA.

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EtoxiClear™: An novel affinity adsorbent for the efficient removal of endotoxin

A number of methods have been adopted for the removal of endotoxin based on adsorption, in particular ion-exchange chromatography.

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