Articles
Articles covering different aspects of downstream processing and manufacture of biotherapeutics
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Read ArticleDetermination of Dynamic Binding Capacity for Chromatography Adsorbent
How to determine the dynamic binding capacity of a chromatography adsorbent.
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Read ArticlePerformance Testing of Packed Columns
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Read ArticleRe-use, Cleaning and sanitization of IsoClear™ Affinity Adsorbents
A scale-down reuse study was performed on an automated chromatography workstation using a 2 mL IsoClear B™ column challenged with 50 CV of plasma per cycle.
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Read ArticleQuality First!
At Astrea Bioseparations we put product quality first and have committed to become the first chromatography adsorbent manufacturer to achieve full GMP compliance!
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Read ArticleScreening for Chromatography Adsorbent Selection and Optimisation for Downstream Processing of Biopharmaceuticals
This article reviews the past and current options for screening of chromatography adsorbents for downstream process development and the use of emergent mixed mode ligand adsorbents for improved adsorb
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Read ArticleScaling up Production
Astrea Bioseparations has been manufacturing chromatography adsorbents on the Isle of Man since 1989. In this article we will update you on the expansion of our adsorbent manufacturing capacity.
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Read ArticleLigand Discovery Projects
Our goal is to provide you with a fully validated bespoke chromatography adsorbent and all the associated process conditions for purification of your target biomolecule.
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Read ArticleCapture and purification of Fab fragments from human polyclonal IgG papain digest using Fabsorbent™ F1P HF
In response to demand we have developed an affinity adsorbent for the capture and purification of antibody fragments.
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Read ArticleIs it really cost effective to develop a custom affinity ligand as a capture step in your downstream process?
We offer an extensive range of off-the-shelf Bioseparation products for the recovery and purification of biologicals as well as purification services including bespoke custom designed chromatography.
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Read ArticleEvolve™ Process Column: Customer Evaluation
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Read ArticleThe Evolve™ Process Column in NIBRT
User friendly and ergonomic; performance is comparable to more expensive columns and the single use aspect compares well to lengthy cleaning cycles.
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Read ArticleEndotoxin removal & β-D-Glucan Interference
EtoxiClear™ has been shown to provide >3.4 log clearance of endotoxin from Fab fragments from an E. coli cell lysate, as well as from proteins such as IgG and HSA.
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Read ArticleEtoxiClear™: An novel affinity adsorbent for the efficient removal of endotoxin
A number of methods have been adopted for the removal of endotoxin based on adsorption, in particular ion-exchange chromatography.
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Read ArticleCapture and purification of human serum albumin from human source plasma using Mimetic Blue® SA HL P6XL
In this application note we describe how human serum albumin is captured and purified from human source plasma using Mimetic Blue® SA HL P6XL.
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Read ArticleCapture and purification of recombinant albumin-fusion proteins using AlbuPure®.
AlbuPure® can be used to capture and purify recombinant albumin-fusion proteins from cell culture supernatants with high purity and recovery.
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Read ArticleEndotoxin Removal from Bench to Process Scale
Endotoxin or lipopolysaccharides (LPS) are highly toxic components of the cell wall of Gram-negative bacteria and are often present in significant amounts in bacterial cell expression systems.
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Read ArticleImmobilised Boronate Ligand Affinity Adsorbents for Glycoproteins
Review useful insights and data highlighting the importance of protein glycosylation in Biopharmaceuticals.
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Read ArticleArticle: Disposable Column options
Interest has been growing in the use of pre-packed disposable chromatography columns and in the use of disposable process fluid contact pathways.
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