Articles

Articles covering different aspects of downstream processing and manufacture of biotherapeutics

  • Removal of Endotoxins - From Bench to Process Scale

    Removal of Endotoxins - From Bench to Process Scale

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  • Removal of Isoagglutinins from IVIG and Plasma Using Affinity Chromatography

    Removal of Isoagglutinins from IVIG and Plasma Using Affinity Chromatography

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  • A Rapid Screening Toolbox for Product Polishing

    A Rapid Screening Toolbox for Product Polishing

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  • EvolveD™ Infographic

    EvolveD™ Infographic

    An infographic on the highlights of our EvolveD™ column range.

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  • Multi-Mode Mimetic Ligand™ Library Infographic

    Multi-Mode Mimetic Ligand™ Library Infographic

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  • Endotoxin Removal Infographic

    Endotoxin Removal Infographic

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  • Determination of Dynamic Binding Capacity for Chromatography Adsorbent

    Determination of Dynamic Binding Capacity for Chromatography Adsorbent

    How to determine the dynamic binding capacity of a chromatography adsorbent.

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  • Performance Testing of Packed Columns

    Performance Testing of Packed Columns

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  • Re-use, Cleaning and sanitization of IsoClear™ Affinity Adsorbents

    Re-use, Cleaning and sanitization of IsoClear™ Affinity Adsorbents

    A scale-down reuse study was performed on an automated chromatography workstation using a 2 mL IsoClear B™ column challenged with 50 CV of plasma per cycle.

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  • Quality First!

    Quality First!

    At Astrea Bioseparations we put product quality first and have committed to become the first chromatography adsorbent manufacturer to achieve full GMP compliance!

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  • Screening for Chromatography Adsorbent Selection and Optimisation for Downstream Processing of Biopharmaceuticals

    Screening for Chromatography Adsorbent Selection and Optimisation for Downstream Processing of Biopharmaceuticals

    This article reviews the past and current options for screening of chromatography adsorbents for downstream process development and the use of emergent mixed mode ligand adsorbents for improved adsorb

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  • Scaling up Production

    Scaling up Production

    Astrea Bioseparations has been manufacturing chromatography adsorbents on the Isle of Man since 1989. In this article we will update you on the expansion of our adsorbent manufacturing capacity.

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  • Ligand Discovery Projects

    Ligand Discovery Projects

    Our goal is to provide you with a fully validated bespoke chromatography adsorbent and all the associated process conditions for purification of your target biomolecule.

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  • Capture and purification of Fab fragments from human polyclonal IgG papain digest using Fabsorbent™ F1P HF

    Capture and purification of Fab fragments from human polyclonal IgG papain digest using Fabsorbent™ F1P HF

    In response to demand we have developed an affinity adsorbent for the capture and purification of antibody fragments.

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  • Is it really cost effective to develop a custom affinity ligand as a capture step in your downstream process?

    Is it really cost effective to develop a custom affinity ligand as a capture step in your downstream process?

    We offer an extensive range of off-the-shelf Bioseparation products for the recovery and purification of biologicals as well as purification services including bespoke custom designed chromatography.

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  • Evolve™ Process Column: Customer Evaluation

    Evolve™ Process Column: Customer Evaluation

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  • The Evolve™ Process Column in NIBRT

    The Evolve™ Process Column in NIBRT

    User friendly and ergonomic; performance is comparable to more expensive columns and the single use aspect compares well to lengthy cleaning cycles.

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  • Endotoxin removal & β-D-Glucan Interference

    Endotoxin removal & β-D-Glucan Interference

    EtoxiClear™ has been shown to provide >3.4 log clearance of endotoxin from Fab fragments from an E. coli cell lysate, as well as from proteins such as IgG and HSA.

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  • EtoxiClear™: An novel affinity adsorbent for the efficient removal of endotoxin

    EtoxiClear™: An novel affinity adsorbent for the efficient removal of endotoxin

    A number of methods have been adopted for the removal of endotoxin based on adsorption, in particular ion-exchange chromatography.

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  • Capture and purification of human serum albumin from human source plasma using Mimetic Blue® SA HL P6XL

    Capture and purification of human serum albumin from human source plasma using Mimetic Blue® SA HL P6XL

    In this application note we describe how human serum albumin is captured and purified from human source plasma using Mimetic Blue® SA HL P6XL.

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