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Strategies for selectivity manipulation in Boronate Affinity Chromatography - Infographic
Removal of Endotoxins - From Bench to Process Scale
Astrea Bioseparations technical poster on removal of Endotoxins.
EvolveD™ Infographic
An infographic on the highlights of Astrea Bioseparations EvolveD™ column range.
Multi-Mode Mimetic Ligand™ Library Infographic
Astrea Bioseparations Infographic for their Multi-Mode Mimetic Ligand™ Library
Endotoxin Removal Infographic
Astrea Bioseparations Endotoxin Removal Infographic for EtoxiClear
Determination of Dynamic Binding Capacity for Chromatography Adsorbent
How to determine the dynamic binding capacity of a chromatography adsorbent.
Performance Testing of Packed Columns
Guidelines from Astrea Bioseparations for Performance Testing of Packed Columns
Re-use, Cleaning and sanitization of IsoClear™ Affinity Adsorbents
A scale-down reuse study was performed on an automated chromatography workstation using a 2 mL IsoClear B™ column challenged with 50 CV of plasma per cycle.
Quality First!
At Astrea Bioseparations we put product quality first and have committed to become the first chromatography adsorbent manufacturer to achieve full GMP compliance!
Screening for Chromatography Adsorbent Selection and Optimisation for Downstream Processing of Biopharmaceuticals
This article reviews the past and current options for screening of chromatography adsorbents for downstream process development and the use of emergent mixed mode ligand adsorbents for improved adsorb
Scaling up Production
Astrea Bioseparations has been manufacturing chromatography adsorbents on the Isle of Man since 1989. In this article we will update you on the expansion of our adsorbent manufacturing capacity.
Ligand Discovery Projects
Our goal is to provide you with a fully validated bespoke chromatography adsorbent and all the associated process conditions for purification of your target biomolecule.
Capture and purification of Fab fragments from human polyclonal IgG papain digest using Fabsorbent™ F1P HF
In response to demand we have developed an affinity adsorbent for the capture and purification of antibody fragments.
Is it really cost effective to develop a custom affinity ligand as a capture step in your downstream process?
We offer an extensive range of off-the-shelf Bioseparation products for the recovery and purification of biologicals as well as purification services including bespoke custom designed chromatography.
Evolve™ Process Column: Customer Evaluation
Feedback from trials of Evolve™ column at a major Biopharmaceutical company, based in USA.
The Evolve™ Process Column in NIBRT
User friendly and ergonomic; performance is comparable to more expensive columns and the single use aspect compares well to lengthy cleaning cycles.
Endotoxin removal & β-D-Glucan Interference
EtoxiClear™ has been shown to provide >3.4 log clearance of endotoxin from Fab fragments from an E. coli cell lysate, as well as from proteins such as IgG and HSA.
EtoxiClear™: An novel affinity adsorbent for the efficient removal of endotoxin
A number of methods have been adopted for the removal of endotoxin based on adsorption, in particular ion-exchange chromatography.
Capture and purification of human serum albumin from human source plasma using Mimetic Blue® SA HL P6XL
In this application note we describe how human serum albumin is captured and purified from human source plasma using Mimetic Blue® SA HL P6XL.