Exploring BioProcess International 2023
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How to determine the dynamic binding capacity of a chromatography adsorbent.
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Guidelines from Astrea Bioseparations for Performance Testing of Packed Columns
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A scale-down reuse study was performed on an automated chromatography workstation using a 2 mL IsoClear B™ column challenged with 50 CV of plasma per cycle.
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At Astrea Bioseparations we put product quality first and have committed to become the first chromatography adsorbent manufacturer to achieve full GMP compliance!
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Astrea Bioseparations has been manufacturing chromatography adsorbents on the Isle of Man since 1989. In this article we will update you on the expansion of our adsorbent manufacturing capacity.
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In response to demand we have developed an affinity adsorbent for the capture and purification of antibody fragments.
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User friendly and ergonomic; performance is comparable to more expensive columns and the single use aspect compares well to lengthy cleaning cycles.
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EtoxiClear™ has been shown to provide >3.4 log clearance of endotoxin from Fab fragments from an E. coli cell lysate, as well as from proteins such as IgG and HSA.
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A number of methods have been adopted for the removal of endotoxin based on adsorption, in particular ion-exchange chromatography.
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