Blog

  • Discovering, Developing and Delivering New Purification Strategies for Novel Therapy Development

    Discovering, Developing and Delivering New Purification Strategies for Novel Therapy Development

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  • Determination of Dynamic Binding Capacity for Chromatography Adsorbent

    Determination of Dynamic Binding Capacity for Chromatography Adsorbent

    How to determine the dynamic binding capacity of a chromatography adsorbent.

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  • Performance Testing of Packed Columns

    Performance Testing of Packed Columns

    Guidelines from Astrea Bioseparations for Performance Testing of Packed Columns

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  • Re-use, Cleaning and sanitization of IsoClear™ Affinity Adsorbents

    Re-use, Cleaning and sanitization of IsoClear™ Affinity Adsorbents

    A scale-down reuse study was performed on an automated chromatography workstation using a 2 mL IsoClear B™ column challenged with 50 CV of plasma per cycle.

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  • Quality First!

    Quality First!

    At Astrea Bioseparations we put product quality first and have committed to become the first chromatography adsorbent manufacturer to achieve full GMP compliance!

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  • Scaling up Production

    Scaling up Production

    Astrea Bioseparations has been manufacturing chromatography adsorbents on the Isle of Man since 1989. In this article we will update you on the expansion of our adsorbent manufacturing capacity.

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  • Capture and purification of Fab fragments from human polyclonal IgG papain digest using Fabsorbent™ F1P HF

    Capture and purification of Fab fragments from human polyclonal IgG papain digest using Fabsorbent™ F1P HF

    In response to demand we have developed an affinity adsorbent for the capture and purification of antibody fragments.

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  • The Evolve® Process Column in NIBRT

    The Evolve® Process Column in NIBRT

    User friendly and ergonomic; performance is comparable to more expensive columns and the single use aspect compares well to lengthy cleaning cycles.

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  • Endotoxin removal & β-D-Glucan Interference

    Endotoxin removal & β-D-Glucan Interference

    EtoxiClear™ has been shown to provide >3.4 log clearance of endotoxin from Fab fragments from an E. coli cell lysate, as well as from proteins such as IgG and HSA.

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  • EtoxiClear™: An novel affinity adsorbent for the efficient removal of endotoxin

    EtoxiClear™: An novel affinity adsorbent for the efficient removal of endotoxin

    A number of methods have been adopted for the removal of endotoxin based on adsorption, in particular ion-exchange chromatography.

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  • Capture and purification of human serum albumin from human source plasma using Mimetic Blue® SA HL P6XL

    Capture and purification of human serum albumin from human source plasma using Mimetic Blue® SA HL P6XL

    In this application note we describe how human serum albumin is captured and purified from human source plasma using Mimetic Blue® SA HL P6XL.

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  • Capture and purification of recombinant albumin-fusion proteins using AlbuPure®

    Capture and purification of recombinant albumin-fusion proteins using AlbuPure®

    AlbuPure® can be used to capture and purify recombinant albumin-fusion proteins from cell culture supernatants with high purity and recovery.

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  • Endotoxin Removal from Bench to Process Scale

    Endotoxin Removal from Bench to Process Scale

    Endotoxin or lipopolysaccharides (LPS) are highly toxic components of the cell wall of Gram-negative bacteria and are often present in significant amounts in bacterial cell expression systems.

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  • Immobilised Boronate Ligand Affinity Adsorbents for Glycoproteins

    Immobilised Boronate Ligand Affinity Adsorbents for Glycoproteins

    Review useful insights and data highlighting the importance of protein glycosylation in Biopharmaceuticals.

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  • Disposable Column options

    Disposable Column options

    Interest has been growing in the use of pre-packed disposable chromatography columns and in the use of disposable process fluid contact pathways.

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