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10% Off First Online Order With Code "FirstOrder10"

Our Bead: The foundation of PuraBead® technology

For more than three decades, Astrea Bioseparations has pioneered agarose-based bead technology. The PuraBead® base matrix was developed using our proprietary solvent-free atomization process, designed to deliver high mechanical strength, low backpressure, and scalability across all stages of bioprocessing. Today, PuraBead® underpins multiple FDA-approved therapeutics and forms the platform for our ion exchange, affinity, hydrophobic interaction, and mixed-mode chromatography resins.

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For over ten years, Astrea Bioseparations has partnered with Thermo Fisher Scientific to reliably manufacture CaptureSelect® affinity resins. In this collaboration, Thermo Fisher’s proprietary ligands are coupled to Astrea Bioseparations' proven PuraBead® base matrix, ensuring robust, scalable resin performance trusted in multiple FDA-approved therapeutics. This long-term partnership highlights our expertise in sustainable bead manufacturing and our commitment to delivering reproducible, industry-leading chromatography solutions.
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Why choose PuraBead® resins?

    Cost efficient with low maintenance

    PuraBead® resins are designed to deliver cost-efficient performance with minimal maintenance requirements. Their robust, highly consistent bead structure supports reliable flow characteristics and predictable separation performance, reducing the risk of batch failures and costly process interruptions. Engineered for durability and reproducibility, PuraBead® resins maintain performance over multiple cycles, helping to lower lifetime operating costs. With dependable lot-to-lot consistency and efficient processing capabilities, they enable streamlined workflows, reduced downtime, and improved overall productivity.
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    Scalable and flexible

    PuraBead® resins are engineered to support scalable and flexible purification processes, enabling smooth transitions from development through to full-scale manufacturing. Their highly uniform bead structure ensures consistent packing and even flow distribution across a range of column sizes, helping maintain performance as processes scale.

    Designed for robustness and reproducibility, PuraBead® resins deliver reliable separation efficiency under varying operating conditions, giving you the flexibility to adapt to changing process demands. This scalability and operational versatility help streamline scale-up, reduce risk, and ensure dependable performance at every stage of production.

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    Complete supply chain control

    PuraBead® resins are manufactured in-house within our fully controlled production facilities, ensuring complete supply chain oversight from raw material sourcing through to final product release. This vertical integration enables stringent quality control, full traceability, and consistent batch-to-batch performance you can rely on.

    By maintaining control over every stage of manufacturing, we enhance product quality, reduce variability, and support dependable lead times. The result is a secure, transparent supply chain that safeguards continuity of supply while delivering the consistent performance required for both established and scaling bioprocessing operations.

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    Browse PuraBead® resin applications

    With exceptional performance, PuraBead® has remarkable sustainability integrated throughout the manufacturing and supply chain

    Experience a day at Astrea Bioseparations’ Isle of Man facility, where our team brings together decades of experience to deliver flexible, high-quality purification solutions.

    Our commitment to precision, reliability, and customer support ensures timely deliveries through a robust supply chain. Together, we are shaping the future of biomanufacturing and advancing scientific breakthroughs.

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    PuraBead® has superior performance to market leading products

    Proprietary PuraBead® technology for excellent porosity
    PuraBead® is produced globally using a novel sustainably-focused atomization technology. The results? Excellent porosity, exceptional flow properties and low back pressure. The tight particle size distribution and consistent bead uniformity make it an ideal choice for consistent performance during every run.

  • Non-uniform bead arrangement due to broad size distribution

  • PuraBead® has a uniform and closely-packed bead arrangement
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    Your ligand, our Bead
    Security of supply
    Manufactured by Astrea Bioseparations for over 20 years

    1000 L batch sizes available
    Continuous batch processing means batch sizes can be tailored according to need

    Reduced environmental impact – More sustainable manufacturing
    There is no requirement for the use of organic solvents in the beading process compared to other market leaders
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    Our capabilities showcase our experience and expertise

    We are expanding to fulfill customer demand

    We are dedicated to expanding our capabilities to support the growth of both our customers and our company. Our vertical integration ensures consistent performance and effective contaminant removal in your existing and scaling bioprocessing.
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    We offer comprehensive support throughout the resin selection process. If off-the-shelf resins aren't the right solution for you, we can offer PuraBead® ligand attachment services, attaching your ligand to our bead and partnering with you on final product finish. We also provide various column extras and accessories, along with full support from our Field Application Scientists at every step of the way.


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