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IsoClear® A XT
IsoClear® A XT
IsoClear® A XT
IsoClear® A XT Alternative Image
IsoClear® A XT Alternative Image
IsoClear® A XT Alternative Image

IsoClear® A XT

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IsoClear® A XT and IsoClear® B XT are highly effective in the removal of anti-A and anti-B isogglutinins from plasma-related products, including IVIG. The IsoClear® XT is a next generation product line, providing an alkali-stable, effective, efficient platform for the clearance of isoagglutinin antibodies, supporting the global demand for safer plasma products.
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Isoagglutinins are plasma-derived IgM and IgG antibodies which recognize and bind to type A or B blood group antigens. The presence of isoagglutinin antibodies in plasma-derived products (particularly plasma for transfusion and IVIG) can give rise to serious side effects, such as haemolysis, depending upon the type of isoagglutinin present (A or B) and the blood type of the recipient. Astrea Bioseparations has developed a next-generation chromatography adsorbent, IsoClear® XT, for the depletion of anti-A and anti-B isoagglutinins. Designed for effective isoagglutinin depletion, this newly developed resin consists of chemically synthesized trisaccharide blood group antigens attached to PuraBead® 6HF support matrix, offering a fully alkali stable Platform. 

Key features

  • Highly specific A and B trisaccharide blood groupantigen ligands
  • Ligands synthesized in house to give security of supply
  • Utilizing PuraBead® 6HF 90 μm agarose support matrix
  • Operational conditions up to 500 cm/h (up to 1 bar)
  • Specific for anti-A, anti-B, and anti-A,B isoagglutinins (IgM and IgG isotypes)
  • Superior isoagglutinin reduction
  • Robust, long-life adsorbents capable of multiple cycles
  • Fully alkali stable

Advantages

  • Applicable with blood-derived compositions such as IVIG
  • Excellent protein recovery including protective antibodies, coagulation, and thrombotic factors expected
  • Easy-to-pack adsorbents
  • Excellent flow properties
  • Comprehensive regulatory support files

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