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Hydrophobic Interaction Chromatography (HIC) Resins

Hydrophobic interaction chromatography (HIC) is a proven technique for the separation and purification of biomolecules based on differences in surface hydrophobicity. It is widely used for protein fractionation, antibody purification, viral vector processing, and aggregate removal, making it a versatile tool across biopharmaceutical workflows.

Astrea Bioseparations offers a broad selection of PuraBead® HIC resins, including Butyl, Hexyl, Octyl, and Phenyl ligands. These resins provide tailored selectivity to match a wide range of molecular properties and purification requirements, supporting applications from early discovery through to large-scale GMP production.

All HIC resins are built on the proprietary PuraBead® base bead, manufactured using our unique atomisation technology. This base delivers high mechanical strength, low backpressure, and reliable scalability, ensuring consistent performance across development and commercial manufacturing.

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Hydrophobic Interaction Chromatography adsorbent with Butyl ligand
Hydrophobic Interaction Chromatography adsorbent with Hexyl ligand
Hydrophobic Interaction Chromatography adsorbent with Octyl ligand
Hydrophobic Interaction Chromatography adsorbent with Phenyl ligand

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