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Ion exchange chromatography resins

Ion exchange chromatography (IEX) is a cornerstone of downstream biopharmaceutical purification, providing high selectivity based on charge interactions. IEX chromatography resins are widely used for the capture, intermediate purification, and polishing of proteins, antibodies, vaccines, and viral vectors. This makes IEX a trusted tool in process development, research, and regulated GMP manufacturing.

Astrea Bioseparations offers a comprehensive portfolio of PuraBead® ion exchange chromatography resins to support diverse bioprocessing strategies. This includes strong exchangers such as Q PuraBead® Edge and SP PuraBead® Edge, designed to deliver enhanced resolution for challenging separations. Established IEX formats such as Q, SP, DEAE, and CM resins are also available, providing flexibility across a wide range of purification strategies.

All PuraBead® IEX resins are built on our proprietary PuraBead® base bead, manufactured using our unique atomization technology. The base matrix delivers high mechanical strength, low backpressure, and reproducible performance, supporting robust scalability from discovery through commercial manufacturing.

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CM PuraBead® HF
CM PuraBead® HF
Ion Exchange (IEX) chromatography adsorbent with weak cation CM ligand
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DEAE PuraBead® HF
DEAE PuraBead® HF
Ion Exchange (IEX) chromatography adsorbent with weak anion DEAE ligand
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Q PuraBead® HF
Q PuraBead® HF
Ion Exchange (IEX) chromatography adsorbent with strong anion Q ligand
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SP PuraBead® HF
SP PuraBead® HF
Ion Exchange (IEX) chromatography adsorbent with strong cation SP ligand
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Q PuraBead® Edge
Q PuraBead® Edge
High resolution anion exchange chromatography resin on the trusted  PuraBead® platform. 
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SP PuraBead® Edge
SP PuraBead® Edge

SP PuraBead® Edge is a next-generation strong CEX adsorbent, featuring a sulphopropyl (SP) group attached to our advanced 65 µm PuraBead® Edge base bead. Our PuraBead® Edge resin is engineered for high-resolution polishing applications, offering short residence times and low back pressure. This resin is designed to enhance separation resolution, ideal when required for the capture and polish of positively charged species.

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