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Mixed-mode chromatography resins

Mixed-mode chromatography resins combine two or more interaction mechanisms within a single ligand, delivering selectivity beyond traditional ion exchange (IEX) or hydrophobic interaction chromatography (HIC). This expanded selectivity makes mixed-mode chromatography a valuable tool for downstream purification of complex biomolecules, including monoclonal antibodies, viral vectors, and recombinant proteins with closely related impurities.

Astrea Bioseparations’ MiMode PuraBead® mixed-mode chromatography resins integrate hydrophobic, anion exchange, and cation exchange interactions to broaden the separation space and improve process performance. These resins are designed to enhance removal of aggregates, host cell proteins, and other process-related impurities, supporting high yield and purity across a range of bioprocessing applications. The portfolio includes hydrophobic, anion exchange, and cation exchange mixed-mode resins tailored to diverse purification strategies.

Built on the proprietary PuraBead® base bead and manufactured using our unique atomization technology, MiMode PuraBead® resins provide high mechanical strength, low backpressure, and reliable scalability. This supports consistent, reproducible performance from early-stage process development through GMP biologics manufacturing.

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MiMode PuraBead® HL4
MiMode PuraBead® HL4
MiMode PuraBead® HL4 is one of four resins in the hydrophobic mixed-mode range that harnesses both hydrophobic and hydrogen-bonding interactions to target proteins and viral particles where other approaches often fail. The hydrophobic family includes MiMode PuraBead® HX1, HX2, HL3, and HL4 resins, each tuned to offer slightly different binding profiles, allowing developers to identify the optimal solution for their molecule.
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MiMode PuraBead® CBX1
MiMode PuraBead® CBX1
MiMode PuraBead® CBX1 is part of the cation exchange mixed-mode family, harnessing cationic, hydrophobic, boronate ester and hydrogen-bonding interactions for powerful purification of positively charged biomolecules, including monoclonal antibodies, enzymes, and proteins with isoelectric points above neutral. By combining multiple binding interaction contributions, these resins provide enhanced flexibility in binding and release, supporting both capture and polishing steps in bioprocess workflows.
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MiMode PuraBead® HX2
MiMode PuraBead® HX2
MiMode PuraBead® HX2 is one of four resins in the hydrophobic mixed-mode range that harnesses both hydrophobic and hydrogen-bonding interactions to target proteins and viral particles where other approaches often fail. The hydrophobic family includes MiMode PuraBead® HX1, HX2, HL3, and HL4 resins, each tuned to offer slightly different binding profiles, allowing developers to identify the optimal solution for their molecule.
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MiMode PuraBead® HL3
MiMode PuraBead® HL3
MiMode PuraBead® HL3 is one of four resins in the hydrophobic mixed-mode range that harnesses both hydrophobic and hydrogen-bonding interactions to target proteins and viral particles where other approaches often fail. The hydrophobic family includes MiMode PuraBead® HX1, HX2, HL3, and HL4 resins, each tuned to offer slightly different binding profiles, allowing developers to identify the optimal solution for their molecule.
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BTXPure®
BTXPure®

BTXPure® is a unique mixed-mode resin for the targeted capture and purification of botulinum toxins.

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MiMode PuraBead® AX1
MiMode PuraBead® AX1
MiMode PuraBead® AX1 is an anion exchange mixed-mode family, harnessing anionic and hydrophobic to provide strong selectivity for negatively charged biomolecules. These resins excel in applications such as nucleic acid clearance, viral purification, and polishing of therapeutic proteins. The mixed-mode design ensures a balance between binding strength and elution control, even in the presence of complex feed streams or high salt environments.
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MiMode PuraBead® HX1
MiMode PuraBead® HX1
MiMode PuraBead® HX1 is one of four resins in the hydrophobic mixed-mode range that harnesses both hydrophobic and hydrogen-bonding interactions to target proteins and viral particles where other approaches often fail. The hydrophobic family includes MiMode PuraBead® HX1, HX2, HL3, and HL4 resins, each tuned to offer slightly different binding profiles, allowing developers to identify the optimal solution for their molecule.
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MiMode® CBX2
MiMode® CBX2
MiMode® CBX2 is part of the cation exchange mixed-mode family, harnessing cationic, hydrophobic, boronate ester and hydrogen-bonding interactions for powerful purification of positively charged biomolecules, including monoclonal antibodies, enzymes, and proteins with isoelectric points above neutral. By combining multiple binding interaction contributions, these resins provide enhanced flexibility in binding and release, supporting both capture and polishing steps in bioprocess workflows.
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MiMode PuraBead® CX1
MiMode PuraBead® CX1
MiMode PuraBead® CX1 is part of the cation exchange mixed-mode family, harnessing cationic, hydrophobic, and hydrogen-bonding interactions for powerful purification of positively charged biomolecules, including monoclonal antibodies, enzymes, and proteins with isoelectric points above neutral. By combining multiple binding interaction contributions, these resins provide enhanced flexibility in binding and release, supporting both capture and polishing steps in bioprocess workflows.
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MiMode PuraBead® CX2
MiMode PuraBead® CX2
MiMode PuraBead® CX2 is part of the cation exchange mixed-mode family, harnessing cationic, hydrophobic, and hydrogen-bonding interactions for powerful purification of positively charged biomolecules, including monoclonal antibodies, enzymes, and proteins with isoelectric points above neutral. By combining multiple binding interaction contributions, these resins provide enhanced flexibility in binding and release, supporting both capture and polishing steps in bioprocess workflows.
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