PuraBead® base matrix

At the heart of Astrea Bioseparations’ chromatography portfolio is the PuraBead® base matrix, a uniquely engineered particle produced using our proprietary atomization technology. Designed to combine strength, consistency, and versatility, PuraBead® provides the foundation for our ion exchange, hydrophobic interaction, affinity, and mixed-mode resin families.

PuraBead® offers exceptional mechanical strength, low backpressure, and excellent flow characteristics, supporting high performance from early development through to large-scale manufacturing. Unlike conventional bead technologies, PuraBead® is manufactured using a solvent-free and sustainable process that minimizes waste while maintaining outstanding reproducibility and robustness for critical bioprocessing applications. 

With a long, proven history in industry, PuraBead® has been trusted for decades in biopharmaceutical manufacturing. The technology underpins multiple FDA-approved therapeutics, demonstrating its reliability and regulatory acceptance. Our expertise also extends to long-standing partnerships, including more than a decade of collaboration manufacturing Thermo Fisher Scientific’s CaptureSelect® range on our PuraBead® base matrix, supporting advanced affinity purification solutions used worldwide.

As the cornerstone of our technology, PuraBead® continues to enable the development and manufacture of life-changing therapies, delivering sustainable, scalable, and industry-proven performance.