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Antibodies, bispecifics & other novel formats

Antibody therapeutics are a cornerstone of modern medicine, driving transformative treatments for cancer, autoimmune, and infectious diseases. Monoclonal antibodies (mAbs) remain the most widely used format, supported by decades of research and proven manufacturing platforms. Yet despite their success, mAbs present ongoing purification challenges, including host cell impurities, aggregation, and variability across expression systems.

As antibody engineering evolves, a new generation of formats is reshaping the therapeutic landscape. Antibody fragments (Fab, scFv), bispecific antibodies (bsAbs), and multispecific or engineered scaffolds promise enhanced tissue penetration, faster clearance, or the ability to engage multiple disease mechanisms simultaneously. These innovative designs broaden therapeutic potential but also introduce greater complexity in downstream processing, where conventional affinity methods such as Protein A may not always be sufficient.

To meet these challenges, a flexible, toolbox-based purification strategy is essential. At Astrea Bioseparations, our portfolio of chromatography solutions is designed to address the evolving landscape of mAb and bsAb purification, delivering scalable, high-performance tools that ensure purity, yield, and consistency for next-generation antibody therapeutics.

Our solutions

    MiMode™ PuraBead® HX2

    MiMode™ PuraBead® HX2 is an appealing, mixed-mode alternative to Protein L for purifying antibody light chain fragments, such as kappa and lambda light chains, Fab and scFv fragments. Using a unique synthetic ligand that demonstrates broad specificity for capture and purification of mAbs and their derivatives, MiMode™ PuraBead® HX2 has an affinity for both kappa and lambda chains. The synthetic nature allows for robust base-stability, and the PuraBead® 6HF base matrix offers stable flow properties even for large-scale manufacturing. These attributes make it an appealing alternative to expensive Protein A and Protein L ligands as a platform technology.  

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    MiMode™ PuraBead® HL3

    MiMode™ PuraBead® HL3 is a mixed-mode resin that gives an alternative purification approach in antibody purification by combining hydrophobic and hydrogen-bond interactions, often removing impurities such as antibody aggregates. It binds all four human IgG subclasses—including IgG3—which some other resins can miss. With high purity, strong viral clearance, and broad IgG compatibility, it’s a great fit when you need a more versatile approach to antibody workflows. 

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    MiMode™ PuraBead® CBX1

    MiMode™ PuraBead® CBX1 is an alternative for antibody purification when you need to target glycosylated forms, such as IgG or remove glycosylated impurities. A highly efficient mixed-mode resin, MiMode™ PuraBead® CBX1 captures glycoprotein variants of antibodies or cleaning up unwanted glycated species from complex mixtures, like those expressed in yeast. The resin works by binding cis-diol-containing structures on antibodies and related impurities, allowing for selective capture or polishing. With a stable PuraBead® base, it delivers good flow and is easy to clean, making it a reliable option for refining antibody prep workflows. 

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      MiMode™ PuraBead® HL4

      MiMode™ PuraBead HL4 is a hydrophobic mixed-mode resin designed with a unique ligand structure attached to PuraBead® 6HF agarose bead support. MiMode™ PuraBead HL4 has a unique operational space compared to other commercially available products and can provide alternative strategies for the removal of problematic impurities. Whilst selectively binding host cell proteins,  MiMode™ PuraBead HL4 also remove host cell DNA, endotoxin, light chain IgG, and high molecular weight aggregates, to yield highly purified biological products with minimal target protein losses.  Due to its highly selective nature and ability to be tuned, by varying the chromatography conditions, this mixed-mode resin removes impurities from a number of different expression systems, including, but not limited to CHO, E. coli, HEK 293, Pichia Pastoris, Saccharomyces Cerevisiae and Spodoptera frugiperda (Sf9 and Sf21). 

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      PuraBead® IEX

      Ion exchange (IEX) resins, such as Q PuraBead® or SP PuraBead® Edge, are a staple in antibody purification, often used after Protein A capture to remove impurities like host cell proteins (HCPs), DNA, and aggregates. They work by separating molecules based on charge differences, making them great for fine-tuning purity and removing closely related contaminants. But because antibody properties vary widely, there’s no one-size-fits-all solution—trying different resin types and formats is often key to finding the best fit for your process. 

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      PuraBead® HIC

      Hydrophobic interaction chromatography (HIC) resins help clean up antibodies by separating out aggregates, misfolded variants, or other hydrophobic impurities that are hard to remove with ion exchange alone. They work under mild conditions using salt gradients, which helps preserve antibody stability. Antibody properties vary widely, there’s no one-size-fits-all solution—trying different resin types and formats is often key to finding the best fit for your process.  

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      EtoxiClear®

      EtoxiClear® is an advanced endotoxin removal resin designed for high-capacity endotoxin removal across pharmaceutical, biotechnology, and research applications. With superior endotoxin clearance, high protein recovery, and process scalability, it ensures efficient and cost-effective removal of bacterial endotoxin from proteins, buffers, and other biological solutions. 

       

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