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10% Off First Online Order With Code "FirstOrder10"

Mix it up with MiMode®

The next generation of mixed-mode chromatography resins

MiMode PuraBead® mixed-mode resins deliver advanced selectivity and robust performance for purification of challenging biologics. Designed to combine multiple binding interactions, the MiMode® range enhances impurity separation, maximizes yield, and simplifies downstream processing. With scalable formats and broad buffer compatibility, MiMode PuraBead® enables flexible, high-performance solutions from early development to manufacturing.

Introducing the newest hydrophobic mixed-mode family, MiMode PuraBead® HX1, HX2, HL3, and HL4 resins, built to take on the toughest separations. The MiMode PuraBead® hydrophobic mixed-mode range harness hydrophobic and hydrogen-bonding mixed-mode interactions for the purification of tricky proteins and viruses where other approaches fall short.

The MiMode® range brings mixed-mode power to your toughest separations—flexible tools, smarter workflows, better results.
 

Choose your chemistry

Choosing the right chemistry is guided by the nature of your target molecule and its physicochemical properties, such as charge, hydrophobicity, and structural complexity. Each MiMode® option is designed to exploit these molecular characteristics, providing unique selectivity for a wide range of biomolecules. If you are uncertain which mode will deliver the best performance, we recommend beginning with a broad screen across all MiMode® chemistries. This approach allows you to quickly identify optimal separation conditions, streamline your purification strategy, and gain confidence that no potential solution has been overlooked.

Hydrophobic

Target the tough ones. Hydrophobic and hydrogen bonding mixed-mode interactions for unique selectivity for tough proteins, viral vectors, and aggregates.

Anion exchange

Versatile and precise. Anion exchange and hydrophobic mixed-mode interactions for nucleic acid clearance, viral purification, and negatively charged microenvironments.

Cation exchange

Powerful capture, smart selectivity. Molecular microenvironments interact with unique cation, hydrophobic, and hydrogen bonding modes.

Screen with confidence

Choose a scalable format that works for your process
96-well plates

The 96-well plate kit is pre-packed with 20 μL of Astrea Bioseparations’ mixed-mode chromatography resin. This format is a ready-to-use method development tool for high-throughput development simultaneous. Compatible with both manual workflows and automated robotic systems.

RoboColumn®

Highly-efficient pre-packed miniaturized columns designed for rapid process development and high-throughput screening. Ready-to-use, these columns are perfectly suited for automated liquid handling systems, ensuring convenience and precision.

1 mL column kits

Easy-to-use pre-packed 1 mL column format of your chosen resins. Perfectly suited to single-use applications, and compatible with automated systems or manual operations, making them a versatile choice for screening and process development.

5 mL column kits

Easy-to-use pre-packed 5 mL column format of your chosen resins. Perfectly suited to single-use applications, and compatible with automated systems or manual operations, making them a versatile choice for screening and process development.

Explore by application

    Recombinant proteins

    Plasma-derived proteins

    Plasma

    MiMode PuraBead® naming guide

    Each product name (e.g., HX1, CX2, AX1) encodes details about its chemistry. See how the names break down.

    Resources

      Brochures

      Videos

      Information

      Blogs

      Application notes

      Perform with power

      Optimize your purification strategy for maximum yield, purity, and process efficiency, no matter your target molecule. Whether you are developing early-stage concepts or refining large-scale manufacturing processes, MiMode® resins are designed to adapt and perform where it matters most. With broad buffer compatibility and robust dual-mode selectivity, they provide the flexibility needed to tackle even the most complex feed streams.

      Our scientists are ready to guide you through every stage of development, from small-scale screening to full cGMP manufacturing, helping you unlock the full potential of MiMode® resins and accelerate your path to reliable, scalable purification.

      Unique selectivity, broad compatibility

      MiMode® mixed-mode resins offer unique selectivity, enabling efficient resolution of complex feed streams. Designed for compatibility with multiple biomolecule classes, these resins provide flexibility across diverse platform processes. Their dual-mode interaction mechanism enhances binding capacity while maintaining high resolution and recovery.

       

      Consistency you can trust

      Manufactured with precision and reproducibility, MiMode® resins ensure consistent performance at every stage of development. Scale confidently with a proven technology that supports both early discovery and full cGMP-manufacturing environments. Our chromatography solutions deliver reliable results under demanding conditions.

       
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